MLL1/WDR5 complex in leukemogenesis and epigenetic regulation

MLL1 is a histone H3Lys4 methyltransferase and forms a complex with WDR5 and other components. It plays important roles in developmental events, transcriptional regulation, and leukemogenesis. MLL1-fusion proteins resulting from chromosomal translocations are molecular hallmarks of a special type of...

Full description

Saved in:
Bibliographic Details
Published inAi zheng Vol. 30; no. 4; pp. 240 - 246
Main Authors Wu, Min, Shu, Hong-Bing
Format Journal Article
LanguageEnglish
Published England College of Life Sciences, Wuhan University, Wuhan,Hubei 430072, P. R. China 01.04.2011
Sun Yat-sen University Cancer Center
Subjects
Animals
DNA Methylation
Epigenesis, Genetic
Histone-Lysine N-Methyltransferase - genetics
Histone-Lysine N-Methyltransferase - metabolism
Histones - metabolism
Humans
Leukemia - genetics
Leukemia - metabolism
Lysine - metabolism
Multiprotein Complexes - genetics
Multiprotein Complexes - metabolism
Myeloid-Lymphoid Leukemia Protein - genetics
Myeloid-Lymphoid Leukemia Protein - metabolism
Review
Transcriptional Activation
人类疾病
分子标志
染色体易位
白血病
融合蛋白
表观
转录调控
遗传调控
MLL1
WDR5
leukemia
signal transduction
epigenetic regulation
Online AccessGet full text

Cover

More Information
Summary:MLL1 is a histone H3Lys4 methyltransferase and forms a complex with WDR5 and other components. It plays important roles in developmental events, transcriptional regulation, and leukemogenesis. MLL1-fusion proteins resulting from chromosomal translocations are molecular hallmarks of a special type of leukemia, which occurs in over 70% infant leukemia patients and often accompanies poor prognosis. Investigations in the past years on leukemogenesis and the MLLI-WDR5 histone H3Lys4 methyltransferase complex demonstrate that epigenetic regulation is one of the key steps in development and human diseases.
Bibliography:MLL1 is a histone H3Lys4 methyltransferase and forms a complex with WDR5 and other components. It plays important roles in developmental events, transcriptional regulation, and leukemogenesis. MLL1-fusion proteins resulting from chromosomal translocations are molecular hallmarks of a special type of leukemia, which occurs in over 70% infant leukemia patients and often accompanies poor prognosis. Investigations in the past years on leukemogenesis and the MLLI-WDR5 histone H3Lys4 methyltransferase complex demonstrate that epigenetic regulation is one of the key steps in development and human diseases.
44-1195/R
MLL1, WDR5, leukemia, epigenetic regulation, signal transduction
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1000-467X
1944-446X
DOI:10.5732/cjc.011.10055