Radionuclide studies of left ventricular function in normal subjects

The effects of age and exercise on cardiac function in a normal male population have been assessed by ECG-gated radionuclide ventriculography. Fifty-nine subjects aged from 25 to 54 years were studied (mean 44 +/- 10 S.D. years). Resting left ventricular ejection fraction (LVEF) was 0.54 +/- 0.07 an...

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Bibliographic Details
Published inNuclear medicine communications Vol. 11; no. 9; p. 607
Main Authors Wathen, C G, Muir, A L, Hannan, W J
Format Journal Article
LanguageEnglish
Published England 01.09.1990
Subjects
Adult
Aging - physiology
Exercise - physiology
Gated Blood-Pool Imaging
Hemodynamics - physiology
Humans
Male
Middle Aged
Reference Values
Ventricular Function, Left - physiology
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Summary:The effects of age and exercise on cardiac function in a normal male population have been assessed by ECG-gated radionuclide ventriculography. Fifty-nine subjects aged from 25 to 54 years were studied (mean 44 +/- 10 S.D. years). Resting left ventricular ejection fraction (LVEF) was 0.54 +/- 0.07 and this increased by 0.07 +/- 0.05 during supine submaximal exercise at 75 watts. The mean increase in cardiac output on exercise was 93 +/- 30%. Stroke volume increased on exercise by 23 +/- 13% and end-systolic volume decreased by 10 +/- 16%. There was a weak correlation (P less than 0.05) between age and change in LVEF on exercise but the increase in cardiac output on exercise was not age dependent. It is important to use an age matched control population in any study of cardiac function.
ISSN:0143-3636
DOI:10.1097/00006231-199009000-00004