Albumin suppresses oxidation of TiNb alloy in the simulated inflammatory environment

• Published in: Journal of biomedical materials research. Part B, Applied biomaterials Vol. 112; no. 4; pp. e35404 - n/a
• Main Authors: Sotniczuk, Agata, Kalita, Damian, Chromiński, Witold, Matczuk, Magdalena, Pisarek, Marcin, Garbacz, Halina
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.04.2024; Wiley Subscription Services, Inc
• Subjects: Albumin; albumin adsorption; Albumins; Alloys; Biomaterials; Biomedical materials; Corrosion; Corrosion mechanisms; Corrosion resistance; Electrochemistry; Hydrogen peroxide; Immune system; implants; Inflammation; Mechanical properties; Modulus of elasticity; nanometric oxide films; Niobium base alloys; Oxidation; Oxide coatings; Oxygen; Reactive oxygen species; Simulation; Surgical implants; Titanium base alloys; titanium β‐phase alloys; albumin adsorption; titanium β‐phase alloys; inflammation; implants; nanometric oxide films; reactive oxygen species
• ISSN: 1552-4973; 1552-4981; 1552-4981
• DOI: 10.1002/jbm.b.35404

Literature data has shown that reactive oxygen species (ROS), generated by immune cells during post‐operative inflammation, could induce corrosion of standard Ti‐based biomaterials. For Ti6Al4V alloy, this process can be further accelerated by the presence of albumin. However, this phenomenon remains unexplored for Ti β‐phase materials, such as TiNb alloys. These alloys are attractive due to their relatively low elastic modulus value. This study aims to address the question of how albumin influences the corrosion resistance of TiNb alloy under simulated inflammation. Electrochemical and ion release tests have revealed that albumin significantly enhances corrosion resistance over both short (2 and 24 h) and long (2 weeks) exposure periods. Furthermore, post‐immersion XPS and cross‐section TEM analysis have demonstrated that prolonged exposure to an albumin‐rich inflammatory solution results in the complete coverage of the TiNb surface by a protein layer. Moreover, TEM studies revealed that H2O2‐induced oxidation and further formation of a defective oxide film were suppressed in the solution enriched with albumin. Overall results indicate that contrary to Ti6Al4V, the addition of albumin to the PBS + H2O2 solution is not necessary to simulate the harsh inflammatory conditions as could possibly be found in the vicinity of a TiNb implant. Albumin tends to form continous layer on Ti‐Nb surface and suppresses its oxidation and dissolution in the simulated inflammatory fluid.