An Efficient Enantioselective Synthesis of Natural Gingerols, the Active Principles of Ginger

A straightforward synthesis of (S)‐gingerols 1–3 has been described. The requisite stereogenic center in the target molecules was introduced by Sharpless asymmetric dihydroxylation using a chiral complex, AD‐mix β. This route is simple and efficient to prepare the products in very good yields....

Full description

Saved in:
Bibliographic Details
Published inHelvetica chimica acta Vol. 98; no. 7; pp. 1009 - 1017
Main Authors Ramesh Reddy, A., Wadavrao, Sachin B., Yadav, J. S., Venkat Narsaiah, A.
Format Journal Article
LanguageEnglish
Published Zürich WILEY-VCH Verlag 01.07.2015
WILEY‐VCH Verlag
Wiley
Wiley Subscription Services, Inc
Subjects
Chemistry
Chemistry, Multidisciplinary
Chiral epoxide
Gingerols
Grignard reaction
Physical Sciences
Principles
Science & Technology
Sharpless asymmetric dihydroxylation
Stereoselective synthesis
CANCER CELLS
Gingerols
PUNGENT PRINCIPLE
DEATH
PGE PRODUCTION
ALCOHOLS
Grignard reaction
Chiral epoxide
BIOSYNTHESIS
ZINGIBER-OFFICINALE
Stereoselective synthesis
DIARYLHEPTANOIDS
Sharpless asymmetric dihydroxylation
Online AccessGet full text

Cover

More Information
Summary:A straightforward synthesis of (S)‐gingerols 1–3 has been described. The requisite stereogenic center in the target molecules was introduced by Sharpless asymmetric dihydroxylation using a chiral complex, AD‐mix β. This route is simple and efficient to prepare the products in very good yields.
Bibliography:istex:191FFE03E174CF1C186E3EA83609E4725F36C37F
ark:/67375/WNG-7QXGM45S-7
ArticleID:HLCA201400393
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.201400393