Amplification and overexpression of the EGF receptor and c-erbB-2 proto-oncogenes in human stomach cancer

We set out to determine the frequency of EGF receptor and c-erbB-2 gene amplification and rearrangement by Southern blotting, and to survey the expression of each of these proto-oncogenes by immunohistochemistry in a parallel series of frozen and routinely-fixed paraffin-embedded gastric cancer spec...

Full description

Saved in:
Bibliographic Details
Published inBritish journal of cancer Vol. 64; no. 1; pp. 79 - 83
Main Authors LEMOINE, N. R, JAIN, S, SILVESTRE, F, LOPES, C, HUGHES, C. M, MCLELLAND, E, GULLICK, W. J, FILIPE, M. I
Format Journal Article
LanguageEnglish
Published Basingstoke Nature Publishing Group 01.07.1991
Subjects
Biological and medical sciences
Blotting, Southern
c-ErbB-2
carcinoma
DNA, Neoplasm - analysis
DNA, Neoplasm - genetics
ErbB Receptors - analysis
ErbB Receptors - genetics
Gastroenterology. Liver. Pancreas. Abdomen
Gene Expression
genes
Humans
Medical sciences
Polymerase Chain Reaction - methods
Protein-Tyrosine Kinases - genetics
Proto-Oncogene Proteins - analysis
Proto-Oncogene Proteins - genetics
Proto-Oncogenes
Receptor, ErbB-2
stomach
Stomach Neoplasms - genetics
Stomach Neoplasms - pathology
Stomach Neoplasms - surgery
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
Human
Stomach
Exploration
Malignant tumor
Gene expression
Gene amplification
Membrane receptor
Epidermal growth factor
Polypeptide
C-Onc gene
Digestive diseases
Molecular biology
Southern blotting
Online AccessGet full text

Cover

More Information
Summary:We set out to determine the frequency of EGF receptor and c-erbB-2 gene amplification and rearrangement by Southern blotting, and to survey the expression of each of these proto-oncogenes by immunohistochemistry in a parallel series of frozen and routinely-fixed paraffin-embedded gastric cancer specimens.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.1991.243