Diffuse idiopathic skeletal hyperostosis prevalence in subjects with severe atherosclerotic cardiovascular diseases

• Published in: Arthritis care & research (2010) Vol. 64; no. 11; pp. 1765 - 1769
• Main Authors: Zincarelli, Carmela, Iervolino, Salvatore, Di Minno, Matteo Nicola Dario, Miniero, Enzo, Rengo, Carlo, Di Gioia, Luisa, Vitale, Dino, Nicolino, Antonio, Furgi, Giuseppe, Pappone, Nicola
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.11.2012; Wiley-Blackwell
• Subjects: Aged; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Body Mass Index; Cardiology. Vascular system; Coronary Artery Bypass - statistics & numerical data; Coronary Artery Disease - epidemiology; Coronary Artery Disease - surgery; Diseases of the osteoarticular system; Diseases of the spine; Female; Heart Failure - epidemiology; Humans; Hyperlipidemias - epidemiology; Hyperostosis, Diffuse Idiopathic Skeletal - epidemiology; Hypertension - epidemiology; Male; Medical sciences; Middle Aged; Obesity - epidemiology; Prevalence; Risk Factors; Severity of Illness Index; Vascular disease; Human; Ankylosing hyperostosis; Prevalence; Diseases of the osteoarticular system; Atherosclerosis; Rheumatology; Cardiovascular disease; Spine disease; Epidemiology
• ISSN: 2151-464X; 2151-4658; 2151-4658
• DOI: 10.1002/acr.21742

Objective Diffuse idiopathic skeletal hyperostosis (DISH) is characterized by ossification of different entheseal sites. Several metabolic factors have been suggested to be involved in DISH development. We assessed the prevalence of DISH and its relationship to traditional vascular risk factors in a cohort of patients diagnosed with cardiovascular diseases. Methods Among the 521 consecutive patients admitted to the heart diseases rehabilitation program in our Rehabilitative Cardiology Unit, only those (n = 436) with recent coronary artery bypass grafting (CABG), a heart valve replacement (HVR), or congestive heart failure (CHF) were enrolled (45 CHF, 338 CABG, and 53 HVR). All patients underwent a rheumatologic examination, blood sample collections, and chest radiographs. Body mass index (BMI), blood pressure, and information about sex, age, smoking habit, and other vascular risk factors were recorded. DISH was established according to the Resnick and Niwayama criteria. Results In the setting (77.1% men), the mean ± SD age was 65.44 ± 9.66 years and the overall prevalence of DISH was 30.3%. A logistic regression analysis showed that both age (odds ratio [OR] 1.076, 95% confidence interval [95% CI] 1.044–1.109; P < 0.001) and obesity (OR 2.28, 95% CI 1.33–3.89; P = 0.003) were significant predictors of the presence of DISH. An increasing OR for the presence of DISH was found for increasing tertiles of age and BMI. No difference resulted according to other traditional vascular risk factors. BMI and age directly correlated with C‐reactive protein levels. Conclusion The overall prevalence of DISH was 30.3%. This is expected because of the study population. Obese and older individuals exhibit a higher risk of DISH development.