Correlative study of human papillomavirus DNA, histopathology and morphometry in cervical condyloma and intraepithelial neoplasia

This study includes 28 intraepithelial squamous lesions of the cervix associated with human papillomavirus (HPV) DNA sequences detected by the Southern blot technique. Objective analyses of the histologic features by morphometric parameters and mitotic index have demonstrated that lesions of HPV typ...

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Bibliographic Details
Published inInternational journal of gynecological pathology Vol. 7; no. 4; p. 297
Main Authors Fu, Y S, Huang, I, Beaudenon, S, Ionesco, M, Barrasso, R, de Brux, J, Orth, G
Format Journal Article
LanguageEnglish
Published United States 01.12.1988
Subjects
Biopsy
Condylomata Acuminata - microbiology
Condylomata Acuminata - pathology
Diagnosis, Differential
DNA, Viral - analysis
Female
Humans
Mitotic Index
Papillomaviridae - genetics
Papillomaviridae - ultrastructure
Uterine Cervical Dysplasia - microbiology
Uterine Cervical Dysplasia - pathology
Uterine Cervical Neoplasms - microbiology
Uterine Cervical Neoplasms - pathology
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Summary:This study includes 28 intraepithelial squamous lesions of the cervix associated with human papillomavirus (HPV) DNA sequences detected by the Southern blot technique. Objective analyses of the histologic features by morphometric parameters and mitotic index have demonstrated that lesions of HPV types 6 and 11 can be distinguished from types 16, 18, and 33 by stepwise discriminant functions. The latter lesions have higher mitotic and cellularity indexes and greater nuclear atypia than the former, supporting a greater degree of epithelial proliferation and abnormality seen in association with HPV types 16/18/33.
ISSN:0277-1691
1538-7151
DOI:10.1097/00004347-198812000-00001