Treatment of spinal cord injury by transplantation of cells via cerebrospinal fluid

• Published in: Neuroscience bulletin Vol. 24; no. 5; pp. 323 - 328
• Main Authors: Liu, Yan, Huang, Hong-Yun
• Format: Journal Article
• Language: English
• Published: Heidelberg Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 01.10.2008
• Subjects: Anatomy; Anesthesiology; Animals; Biomedical and Life Sciences; Biomedicine; Cell Transplantation - methods; Cerebrospinal Fluid - cytology; Cerebrospinal Fluid - physiology; Human Physiology; Humans; Minireview; Nerve Regeneration - physiology; Neurology; Neurosciences; Pain Medicine; Spinal Cord Injuries - pathology; Spinal Cord Injuries - surgery; cell transplantation; 蛛网膜下腔; subarachnoid space; cerebrospinal fluid; 细胞移植; 脑脊液; Q42
• ISSN: 1673-7067; 1995-8218
• DOI: 10.1007/s12264-008-0618-0

It is very important to probe into the axonal regeneration and functional recovery of central nervous system (CNS) after implantation of cells into cerebrospinal fluid (CSF) for spinal cord injury (SCI). Transplantation of cells via CSF poses great potentials for SCI in clinic. Studies on administration of cells via CSF indicate that the method is safe and convenient. The method is more suitable to treating multiple lesions of the CNS since it does not produce open lesions. However, there are disputes over its promotion effects on axonal regeneration and functional recovery of spinal cord after injury; and some questions, such as the mechanisms of functional recovery of spinal cord, the proper time window of cell transplantation, and cell types of transplantation, still need to be handled. This review summarized the method of cell transplantation via CSF for treatment of SCI.