Urinary basic fibroblast growth factor: a noninvasive marker of progressive cystic renal disease in a child

Autosomal recessive polycystic kidney disease (ARPKD) is a hereditary condition with an estimated incidence of 1 in 20,000 live births. Various growth factors have been implicated in the causation of this disease. We describe a child with ARPKD whose levels of urinary basic fibroblast growth factor...

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Bibliographic Details
Published inAmerican journal of medical genetics Vol. 93; no. 2; p. 132
Main Authors Gupta, G K, Milner, L, Linshaw, M A, McCauley, R G, Connors, S, Folkman, J, Bianchi, D W
Format Journal Article
LanguageEnglish
Published United States 17.07.2000
Subjects
Adult
Biomarkers - urine
Child, Preschool
Disease Progression
Female
Fibroblast Growth Factor 2 - urine
Humans
Male
Nephrectomy
Polycystic Kidney, Autosomal Recessive - pathology
Polycystic Kidney, Autosomal Recessive - surgery
Polycystic Kidney, Autosomal Recessive - urine
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Summary:Autosomal recessive polycystic kidney disease (ARPKD) is a hereditary condition with an estimated incidence of 1 in 20,000 live births. Various growth factors have been implicated in the causation of this disease. We describe a child with ARPKD whose levels of urinary basic fibroblast growth factor (bFGF) were markedly elevated. The concentrations of bFGF increased further following right nephrectomy, in response to the compensatory growth of the remaining kidney. We hypothesize that measurement of urinary bFGF may be useful as a noninvasive marker to assess progression of cystic renal development.
ISSN:0148-7299
DOI:10.1002/1096-8628(20000717)93:2<132::AID-AJMG10>3.0.CO;2-#