Indocyanine green angiography in patients with human T cell-lymphotropic virus type 1 uveitis

• Published in: Graefe's archive for clinical and experimental ophthalmology Vol. 240; no. 2; pp. 101 - 105
• Main Authors: SAKURAI, Toshiya, YUKAWA, Eiichi, HARA, Yoshiaki, MIYATA, Norio, MOCHIZUKI, Manabu
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.02.2002; Springer Nature B.V
• Subjects: Adult; Aged; Antibodies, Viral - analysis; Biological and medical sciences; Capillary Permeability; Choroid - blood supply; Choroid - pathology; Choroid Diseases - diagnosis; Choroid Diseases - virology; Coloring Agents; DNA, Viral - analysis; Eye Infections, Viral - diagnosis; Eye Infections, Viral - virology; Female; Fluorescein Angiography - methods; HTLV-I Infections - diagnosis; HTLV-I Infections - virology; Human T-lymphotropic virus 1 - genetics; Human T-lymphotropic virus 1 - immunology; Human T-lymphotropic virus 1 - isolation & purification; Human viral diseases; Humans; Indocyanine Green; Infectious diseases; Male; Medical sciences; Middle Aged; Polymerase Chain Reaction; Uveitis - diagnosis; Uveitis - virology; Viral diseases; Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye; Human; Evaluation; Radiodiagnosis; Angiography; Retroviridae; Choroid; Exploration; Uvea disease; Inflammation; Indocyanine green; Infection; Virus; Case study; Eye disease; Viral disease; Uveitis; Diagnosis; HTLV-I virus
• ISSN: 0721-832X; 1435-702X
• DOI: 10.1007/s00417-001-0389-z

To determine the indocyanine green (ICG) angiographic features and to evaluate the choroidal involvement of human T-cell lymphotropic virus type 1 (HTLV-1)-associated uveitis. We performed ICG angiography using scanning laser ophthalmoscopy in 54 eyes of 27 patients (8 men and 19 women) diagnosed with HTLV-1 uveitis. The patient's mean age was 51.5 years with a range of 24-65 years. The early phase of ICG angiography revealed ICG leakage from the choroidal vessels in the posterior pole, hyperfluorescent spots that which were not detected with fluorescein angiography, and small hypofluorescent lesions in the macula which most likely corresponded to microcirculatory disturbances in the choriocapillaris. We suggest that the ICG angiographic findings reflect choroidal lesions such as infiltration with leukocytes and edema. ICG angiography may provide useful information on choroidopathy in HTLV-1 uveitis.