Joint associations of sedentary behavior and domain-specific physical activity on C-reactive protein in Korea

• Published in: Preventive medicine Vol. 182; p. 107944
• Main Authors: Park, Sungjin, Son, Heeseung
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2024
• Subjects: C-reactive protein; Inflammatory marker; Occupational health practices; Physical activity; Sedentary behavior; CRP; Sedentary behavior; OPA; T2DM; KNHANES; C-reactive protein; OR; Physical activity; TPA; CI; Occupational health practices; SB; Inflammatory marker; CVD; PA; KCDC; GPAQ; IRB; Hs-CRP; WBC; LPA; WHO
• ISSN: 0091-7435; 1096-0260
• DOI: 10.1016/j.ypmed.2024.107944

Sedentary behavior (SB) and physical activity (PA) exert opposing effects on inflammatory markers. This study examined the associations of a more subdivided combination of PA and SB with high-sensitivity C-reactive protein (hs-CRP). Using the 2014–2019 Korean National Health and Nutrition Examination Survey, this cross-sectional study analyzed 20,541 adults. The independent variables were SB, defined as ≥10 h of sitting per day, and three domains of PA: occupational PA (OPA) during work, leisure-time PA (LPA) during leisure time, and transportation PA (TPA) or active commuting. The dependent variable was hs-CRP ≥ 1.0 mg/L. Besides exploring the individual association of SB and each PA with hs-CRP, the combined association of SB and each PA with hs-CRP was also examined using multiple logistic regression. The analyses indicated that concurrent exposure to SB and OPA (odds ratio [OR] 1.36, 95% confidence interval [CI] 1.02–1.80) significantly raised the likelihood of increased hs-CRP, while SB without LPA (OR 1.26, 95% CI 1.11–1.41) or TPA (OR 1.19, 95% CI 1.08–1.31) significantly increased risk of higher hs-CRP, compared to their respective reference. The absence of non-occupational PA such as LPA or TPA combined with SB was associated with the increased hs-CRP risk, whereas OPA increased the risk when present concurrently with SB. Reducing SB and OPA while increasing LPA and TPA, is necessary to reduce inflammatory conditions. •Sedentary behavior (SB) has a negative impact on inflammatory markers.•Physical activity (PA) occurs in leisure (LPA), work (OPA), and transit (TPA).•SB with OPA was related with elevated high-sensitivity C-reactive protein (hs-CRP).•SB without LPA or TPA was associated with higher hs-CRP levels.•Reducing SB and OPA, and raising LPA and TPA can reduce systemic inflammation.