Immunotherapy of Autochthonous Rat Methylcholanthrene-Induced Sarcomas with a Mixture of Allogeneic Tumor Cells and BCG-CWS

Experimental immunotherapy with a mixture of allogeneic tumor cells and BCG cell-wall skeleton (BCG-CWS) was carried out against established autochthonous fibrosarcomas induced by 3-methylcholanthrene (MCA) in the subcutaneous tissue of rats. The inhibitory effect on growth in the early stage, tumor...

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Bibliographic Details
Published inThe Tohoku Journal of Experimental Medicine Vol. 130; no. 1; pp. 49 - 53
Main Authors KUDO, HAJIME, SUGA, MICHIO, WAGA, TAKASHI, OGASAWARA, MASAMICHI, SATO, TATSUSUKE, USUBUCHI, ISAMU
Format Journal Article
LanguageEnglish
Published Tohoku University Medical Press 1980
Subjects
allogeneic tumor cells
BCG-CWS
immunotherapy
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Summary:Experimental immunotherapy with a mixture of allogeneic tumor cells and BCG cell-wall skeleton (BCG-CWS) was carried out against established autochthonous fibrosarcomas induced by 3-methylcholanthrene (MCA) in the subcutaneous tissue of rats. The inhibitory effect on growth in the early stage, tumor-size up to 2 cm in diameter, was significantly observed. No significant difference, however, was shown as compared with the effect of treatment with allogeneic tumor cells alone. That is to say, a more effective inhibition of growth due to the addition of BCG-CWS was not demonstrated.
ISSN:0040-8727
1349-3329
DOI:10.1620/tjem.130.49