Synthesis of pyrrole carboxamide nucleotide triphosphates—putative labelled nucleotide analogues

• Published in: Tetrahedron letters Vol. 43; no. 12; pp. 2289 - 2291
• Main Authors: Nairne, R.James D., Pickering, Lea, Smith, Clifford L.
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 18.03.2002; Elsevier
• Subjects: amides; Chemistry; Chemistry, Organic; nucleic acid analogues; nucleotides; Physical Sciences; pyrroles; Science & Technology; amides; pyrroles; nucleotides; nucleic acid analogues

The syntheses of pyrrole carboxamide nucleotide triphosphates and the initial results of their incorporation by Klenow fragment are reported. The two pyrrole carboxamide nucleotide triphosphates have been prepared and screened as Klenow fragment substrates.