Parecoxib prevents complications in hepatocellular carcinoma patients receiving hepatic transarterial chemoembolization: a prospective score-matched cohort study

• Published in: Oncotarget Vol. 7; no. 19; pp. 27938 - 27945
• Main Authors: Zhou, Zhong-Guo, Chen, Jin-Bin, Qiu, Hai-Bo, Wang, Ruo-Jing, Chen, Jian-Cong, Xu, Li, Chen, Min-Shan, Zhang, Yao-Jun
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 10.05.2016
• Subjects: Adult; Aged; Antineoplastic Agents - administration & dosage; Carcinoma, Hepatocellular - blood; Carcinoma, Hepatocellular - therapy; Chemoembolization, Therapeutic - adverse effects; Cyclooxygenase 2 Inhibitors - therapeutic use; Female; Fever - epidemiology; Fever - prevention & control; Humans; Isoxazoles - therapeutic use; Length of Stay - statistics & numerical data; Liver - physiopathology; Liver Function Tests; Liver Neoplasms - blood; Liver Neoplasms - therapy; Male; Middle Aged; Pain Measurement; Pain, Postoperative - epidemiology; Pain, Postoperative - prevention & control; Palliative Care - methods; Postoperative Nausea and Vomiting; Propensity Score; Prospective Studies; Research Paper; parecoxib; transarterial chemoembolization; hepatocellular carcinoma
• ISSN: 1949-2553; 1949-2553
• DOI: 10.18632/oncotarget.8560

Transarterial chemoembolization(TACE) is the palliative treatment of choice for patients with unresectable hepatocellular carcinoma (HCC). The 242 patients prospectively enrolled in this study were diagnosed with HCC and received TACE at Sun Yat-Sen University Cancer Center between October 2014 and March 2015. Patients were divided into study and control groups based on whether parecoxib sodium was administered postoperatively. Postoperative pain, body temperature, vomiting, changes in liver function, physical activity level, length of hospital stay, and tumor control were evaluated. Compared to the control group after propensity score matching, the study group presented less severe postoperative fever. The daily maximum temperatures in the study and control groups were 37.39 vs. 37.82°C on postoperative day 1 (P < 0.001), 37.10 vs. 37.51°C on day 2 (P < 0.001), and 36.90 vs. 37.41°C on day 3 (P < 0.001). The study group also exhibited greater physical activity (P < 0.05) and had shorter hospital stays (7.21 days vs. 7.92 days, P = 0.041). There were no differences in pain scores. Thus administration of parecoxib sodium to HCC patients after TACE effectively relieved fever, promoted postoperative recovery, and shortened the hospital stay.