Tetracycline: Effect on Osteogenesis in vitro

• Published in: Science (American Association for the Advancement of Science) Vol. 149; no. 3686; pp. 870 - 872
• Main Author: SAXEN, L
• Format: Journal Article
• Language: English
• Published: United States American Association for the Advancement of Science 20.08.1965
• Subjects: Animals; Bone and Bones; Bone Development; Bone formation; Bones; Calcification, Physiologic; Calcium; Chlorophylls; Diatoms; Embryology; Fluorescence; Ice; In Vitro Techniques; Mice; Osteogenesis; Pharmacology; Photomicrography; Sea ice; Sea water; Straits; Tetracycline; Toxicology; Ulna; FLUORESCENCE; PHARMACOLOGY; EXPERIMENTAL LAB STUDY; BONE DEVELOPMENT; CALCIFICATION, PHYSIOLOGIC; EMBRYOLOGY; MICE; PHOTOMICROGRAPHY; TETRACYCLINE; TOXICOLOGIC REPORT

Tetracycline hydrochloride added to cultures of rudiments of embryonic bone in a concentration of 1 microgram per milliliter prevents mineralization of the bones and is found throughout the calcified zones. The inhibition is reversible; upon transfer of a treated culture to a normal medium, minerali...