Tetracycline: Effect on Osteogenesis in vitro

Tetracycline hydrochloride added to cultures of rudiments of embryonic bone in a concentration of 1 microgram per milliliter prevents mineralization of the bones and is found throughout the calcified zones. The inhibition is reversible; upon transfer of a treated culture to a normal medium, minerali...

Full description

Saved in:
Bibliographic Details
Published inScience (American Association for the Advancement of Science) Vol. 149; no. 3686; pp. 870 - 872
Main Author SAXEN, L
Format Journal Article
LanguageEnglish
Published United States American Association for the Advancement of Science 20.08.1965
Subjects
Animals
Bone and Bones
Bone Development
Bone formation
Bones
Calcification, Physiologic
Calcium
Chlorophylls
Diatoms
Embryology
Fluorescence
Ice
In Vitro Techniques
Mice
Osteogenesis
Pharmacology
Photomicrography
Sea ice
Sea water
Straits
Tetracycline
Toxicology
Ulna
FLUORESCENCE
PHARMACOLOGY
EXPERIMENTAL LAB STUDY
BONE DEVELOPMENT
CALCIFICATION, PHYSIOLOGIC
EMBRYOLOGY
MICE
PHOTOMICROGRAPHY
TETRACYCLINE
TOXICOLOGIC REPORT
Online AccessGet full text

Cover

More Information
Summary:Tetracycline hydrochloride added to cultures of rudiments of embryonic bone in a concentration of 1 microgram per milliliter prevents mineralization of the bones and is found throughout the calcified zones. The inhibition is reversible; upon transfer of a treated culture to a normal medium, mineralization proceeds normally but maldeveloped bones result.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.149.3686.870