Redox TRPs in Ischemia-Reperfusion Injury and Their Pharmacological Value

Ischemia-reperfusion injury (IRI) is a complex phenomenon. Although researchers have long been aware of IRI, its complex signaling events and potential therapeutic targets are still an active research area. The role of reactive oxygen species in IRI has garnered great interest among scientists. Rece...

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Bibliographic Details
Published inFrontiers in bioscience (Landmark. Print) Vol. 29; no. 5; p. 170
Main Authors Ren, Ming, Sun, Lu-Lu, Tu, Yu-Chi, Feng, Li, Yao, Li-Jun
Format Journal Article
LanguageEnglish
Published Singapore IMR Press 30.04.2024
Subjects
Animals
Humans
ischemia reperfusion injury
Oxidation-Reduction
reactive oxygen species
Reactive Oxygen Species - metabolism
redox-sensitive trp channels
Reperfusion Injury - metabolism
Signal Transduction
transient receptor potential channels
Transient Receptor Potential Channels - metabolism
ischemia reperfusion injury
transient receptor potential channels
redox-sensitive TRP channels
reactive oxygen species
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Summary:Ischemia-reperfusion injury (IRI) is a complex phenomenon. Although researchers have long been aware of IRI, its complex signaling events and potential therapeutic targets are still an active research area. The role of reactive oxygen species in IRI has garnered great interest among scientists. Recent studies have found that reactive oxygen species produced by IRI can activate redox-sensitive transient receptor potential channels (redox TRPs). The discovery of redox TRPs provides a new perspective for understanding the mechanism of IRI.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
ISSN:2768-6701
2768-6698
DOI:10.31083/j.fbl2905170