Platelet monoamine oxidase activity and 5-hydroxytryptamine uptake in agoraphobic patients

Platelet MAO activity and platelet serotonin uptake were determined in 20 agoraphobic and 16 neurotic depressive out-patients, and 19 healthy volunteers. Agoraphobic patients were characterised by significantly higher mean values of platelet MAO activity compared with the other two groups, while neu...

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Bibliographic Details
Published inBritish journal of psychiatry Vol. 155; p. 680
Main Authors Flaskos, J, Theophilopoulos, N, George, A J
Format Journal Article
LanguageEnglish
Published England 01.11.1989
Subjects
Adult
Agoraphobia - blood
Agoraphobia - diagnosis
Agoraphobia - metabolism
Blood Platelets - enzymology
Blood Platelets - metabolism
Depressive Disorder - blood
Depressive Disorder - diagnosis
Depressive Disorder - metabolism
Diagnosis, Differential
Female
Humans
Male
Monoamine Oxidase - metabolism
Psychiatric Status Rating Scales
Serotonin - metabolism
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Summary:Platelet MAO activity and platelet serotonin uptake were determined in 20 agoraphobic and 16 neurotic depressive out-patients, and 19 healthy volunteers. Agoraphobic patients were characterised by significantly higher mean values of platelet MAO activity compared with the other two groups, while neurotic depressive patients exhibited significantly higher maximum platelet serotonin uptake velocity. These findings are compatible with an abnormality in the uptake and metabolism of serotonin.
ISSN:0007-1250
DOI:10.1192/bjp.155.5.680