Cerebral Expression of the Neuregulin-1 Gene NRG1 during Induced Spatial Memory Impairment and Its Reversal in Aging Mice

• Published in: Bulletin of experimental biology and medicine Vol. 174; no. 1; pp. 18 - 21
• Main Authors: Gruden, M. A., Davydova, T. V., Ratmirov, A. M., Sewell, R. D. E.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.11.2022; Springer; Springer Nature B.V
• Subjects: Aging; Alzheimer's disease; Amnesia; Amyloidogenesis; Amyloidogenic Proteins - pharmacology; Animal memory; Animals; Antibodies; Antibodies - administration & dosage; Apoptosis; Biomedical and Life Sciences; Biomedicine; Brain research; Calgranulin B - pharmacology; Cell Biology; Cerebellum; Cerebrum; ErbB protein; ErbB Receptors - metabolism; Experiments; Fibrils; Gene expression; Genes; Glutamate; Glutamic Acid - immunology; Glutamic Acid - metabolism; Inflammation; Internal Medicine; Intranasal administration; Kinases; Laboratory Medicine; Long term memory; Memory; Memory Disorders - chemically induced; Memory Disorders - metabolism; Mice; Mice, Inbred C57BL; Nervous system; Neuregulin; Neuregulin 1; Neuregulin-1 - genetics; Neurogenesis; Neurophysiology; Neurosciences; Pathology; Physiology; Prefrontal cortex; Proteins; Spatial Memory; Viral antibodies; spatial amnesia; NRG1 gene; antibodies to glutamate; S100A9 fibrils; Alzheimer’s disease
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-022-05639-4

We studied the effects of chronic intranasal administration of amyloidogenic fibrils of the proinflammatory protein S100A9 alone or in combination with glutamate antibodies on the expression of the neuregulin-1 gene ( NRG1 ), a regulator of various physiological processes, in particular, regulation of neurogenesis and apoptosis, in the hippocampus, prefrontal cortex, and cerebellum of aging C57BL/6 mice under conditions of long-term memory disturbances. Under conditions of amnesia induced by S100A9 fibrils, pronounced (>90%) blockade of the expression of the NRG1 gene was found in all cerebral structures. Glutamate antibodies prevented/corrected disturbances in the cerebral expression of the NRG1 gene, thereby maintaining the activity of the NRG1/ErbB molecular signaling system, probably associated with the formation of spatial memory.