Prevalence of genotypic resistance in untreated HIV patients in Spain

• Published in: European journal of clinical microbiology & infectious diseases Vol. 21; no. 4; pp. 310 - 313
• Main Authors: EIROS, J. M, LABAYRU, C, HERNANDEZ, B, ORTEGA, M, BACHILLER, P, ORTIZ DE LEJARAZU, R
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.04.2002; Springer Nature B.V
• Subjects: Acquired immune deficiency syndrome; Adolescent; Adult; Aged; AIDS; Anti-HIV Agents - pharmacology; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiretroviral drugs; Antiviral agents; Biological and medical sciences; Child; Drug Resistance, Multiple, Viral; Female; Genetic Variation; HIV; HIV - drug effects; HIV - enzymology; HIV - genetics; HIV - physiology; HIV Infections - epidemiology; HIV Infections - virology; HIV Reverse Transcriptase - genetics; HIV Reverse Transcriptase - metabolism; Human immunodeficiency virus; Human viral diseases; Humans; Infections; Infectious diseases; Male; Medical sciences; Middle Aged; Mutation; Mutation - genetics; Patients; Pharmacology. Drug treatments; Polymerase chain reaction; Retrospective Studies; Spain - epidemiology; Statistical significance; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Europe; Spain; United States > US; Immunopathology; Prevalence; Genetic variant; Retroviridae; Genotype; AIDS; Immune deficiency; Lentivirus; Epidemiology; Infection; Virus; Resistance; Viral disease; Primary; Antiviral; Human immunodeficiency virus
• ISSN: 0934-9723; 1435-4373
• DOI: 10.1007/s10096-002-0711-7

The aims of this retrospective study were to assess the prevalence of primary genotypic resistance to antiretroviral drugs in untreated HIV patients in Spain using the line probe assay and to determine its possible relationship to several epidemiological variables. The global prevalence of primary resistance was 12.5%. Primary mutations in the reverse transcriptase gene were found in two (2.2%) samples: M41L, K70R and M184 V were found in one sample and K70R in another. Primary mutations in the protease gene were detected in 12% of cases; V82A was the mutation most frequently detected (11/12, 91.6%). No statistical significance was found for any of the epidemiological variables studied. In conclusion, the prevalence of primary resistance detected is similar to that found by other authors.