Complete regression of primary gastric plasmacytoma following Helicobacter pylori eradication

• Published in: Annals of hematology Vol. 82; no. 9; pp. 589 - 592
• Main Authors: PAPADAKI, H. A, SKORDILIS, P, MINADAKIS, G, ROUSSOMOUSTAKAKI, M, KATRINAKIS, G, PSYLLAKI, M, TZARDI, M, KOUROUMALIS, E, ELIOPOULOS, G. D
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.09.2003; Springer Nature B.V
• Subjects: Antibodies, Bacterial - blood; Biological and medical sciences; Breath Tests; Gastric Mucosa - microbiology; Gastroenterology. Liver. Pancreas. Abdomen; Helicobacter Infections - diagnosis; Helicobacter Infections - drug therapy; Helicobacter pylori - immunology; Humans; Immunoglobulin kappa-Chains - analysis; Immunohistochemistry; Male; Medical sciences; Middle Aged; Neoplasm Staging; Plasmacytoma - drug therapy; Plasmacytoma - microbiology; Plasmacytoma - pathology; Stomach Neoplasms - drug therapy; Stomach Neoplasms - microbiology; Stomach Neoplasms - pathology; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumors; Urease - analysis; Human; Stomach; Plasma cell tumor; Spirillales; Spirillaceae; Regression; Male; Malignant hemopathy; Eradication; Primary gastric plasmacytoma; Case study; Antibiotic; Helicobacter pylori; Myelomatosis; Extramedullary plasmacytoma; Lymphoproliferative syndrome; Digestive diseases; Bacteria; Evolution; Plasmacytoma; Gastric disease
• ISSN: 0939-5555; 1432-0584
• DOI: 10.1007/s00277-003-0701-6

We describe the first case of a primary gastric plasmacytoma stage I completely regressed following Helicobacter pylori (H.pylori) eradication. The patient, a 61-year-old man, had a long history of chronic gastritis and gastric ulcers with recurrent gastrointestinal hemorrhage. Diagnosis of H.pylori infection was based on the positive urease breath test, the elevated titers of serum anti- H.pylori antibodies, and the detection of the bacterium in gastric mucosa biopsy specimens. Diagnosis of gastric plasmacytoma was based on the findings of histopathology, immunocytochemistry and in situ hybridization. Eradication of H.pylori with antibiotics was followed by disappearance of endoscopic and histopathologic features of the gastric tumor 3 months after the completion of the treatment. No relapse has been documented 20 months after the initial diagnosis of plasmacytoma. A possible causal relationship between the tumor and the underlying H.pylori infection is discussed.