4-hydroxy-2-quinolones. 202. Synthesis, chemical and biological properties of 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid alkylamides

• Published in: Chemistry of heterocyclic compounds (New York, N.Y. 1965) Vol. 48; no. 2; pp. 320 - 326
• Main Authors: Ukrainets, I. V., Bevz, O. V., Mospanova, E. V., Savchenkova, L. V., Yankovich, S. I.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.05.2012; Springer Nature
• Subjects: Chemistry; Chemistry and Materials Science; Chemistry, Organic; Organic Chemistry; Pharmacy; Physical Sciences; Science & Technology; amidation; 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamides; analgesic activity; bromination; ANALGESICS

In continuation of the search for potential analgesics amongst 4-hydroxyquinol-2-one derivatives we have proposed and carried out a preparative method of synthesis of 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid alkylamides. It has been shown that bromination of 4-hydroxy-6,7...