4-hydroxy-2-quinolones. 202. Synthesis, chemical and biological properties of 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid alkylamides

In continuation of the search for potential analgesics amongst 4-hydroxyquinol-2-one derivatives we have proposed and carried out a preparative method of synthesis of 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid alkylamides. It has been shown that bromination of 4-hydroxy-6,7...

Full description

Saved in:
Bibliographic Details
Published inChemistry of heterocyclic compounds (New York, N.Y. 1965) Vol. 48; no. 2; pp. 320 - 326
Main Authors Ukrainets, I. V., Bevz, O. V., Mospanova, E. V., Savchenkova, L. V., Yankovich, S. I.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.05.2012
Springer Nature
Subjects
Chemistry
Chemistry and Materials Science
Chemistry, Organic
Organic Chemistry
Pharmacy
Physical Sciences
Science & Technology
amidation
4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamides
analgesic activity
bromination
ANALGESICS
Online AccessGet full text

Cover

More Information
Summary:In continuation of the search for potential analgesics amongst 4-hydroxyquinol-2-one derivatives we have proposed and carried out a preparative method of synthesis of 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid alkylamides. It has been shown that bromination of 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid allylamide using an equivalent of molecular bromine occurs with a conventional addition of the halogen to the allyl double bond and not with halocyclization. The results of the study of the analgesic properties of the compounds prepared are presented.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-012-0992-4