Synthesis and antibacterial activity of pyrroloaryl-substituted oxazolidinones

A novel series of oxazolidinones containing a pyrroloaryl substituent was synthesized and screened against a representative panel of susceptible and resistant Gram-positive bacteria. Several members of this series were found to have antibacterial activity comparable to or better than linezolid. A no...

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 13; no. 23; pp. 4173 - 4177
Main Authors Paget, Steven D., Foleno, Barbara D., Boggs, Christine M., Goldschmidt, Raul M., Hlasta, Dennis J., Weidner-Wells, Michele A., Werblood, Harvey M., Wira, Ellyn, Bush, Karen, Macielag, Mark J.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.12.2003
Subjects
Acetamides - chemical synthesis
Acetamides - chemistry
Acetamides - pharmacology
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Gram-Positive Bacteria - drug effects
Linezolid
Microbial Sensitivity Tests
Oxazolidinones - chemical synthesis
Oxazolidinones - chemistry
Oxazolidinones - pharmacology
Structure-Activity Relationship
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Summary:A novel series of oxazolidinones containing a pyrroloaryl substituent was synthesized and screened against a representative panel of susceptible and resistant Gram-positive bacteria. Several members of this series were found to have antibacterial activity comparable to or better than linezolid. A novel series of oxazolidinones containing a pyrroloaryl substituent was synthesized and screened against a representative panel of susceptible and resistant Gram-positive bacteria. Several members of this series were found to have antibacterial activity comparable to or better than linezolid.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2003.08.031