Interaction of tralomethrin, tralocythrin, and related pyrethroids in Na + channels of insect and mammalian neuronal cells

• Published in: Pesticide biochemistry and physiology Vol. 24; no. 3; pp. 306 - 316
• Main Authors: Roche, Michel, Frelin, Christian, Bruneau, Pierre, Meinard, Colette
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 01.01.1985; Elsevier
• Subjects: Biological and medical sciences; Chemical control; Control; Fundamental and applied biological sciences. Psychology; Generalities; MICE; NERF; NERVES; NERVIOS; PERIPLANETA; PERIPLANETA AMERICANA; Phytopathology. Animal pests. Plant and forest protection; PIRETRINAS; Protozoa. Invertebrates; PYRETHRINE; PYRETHRINS; RATON; SODIO; SODIUM; SOURIS; Blattodea; Sodium Ions; Insecticide; Toxicity; Insecta; Electrophysiology; Pyrethroids; Nervous system; Biological material; Periplaneta americana; Vertebrata; Mammalia; Neuron; Arthropoda; Invertebrata; Mechanism of action; Dictyoptera
• ISSN: 0048-3575; 1095-9939
• DOI: 10.1016/0048-3575(85)90141-5

The neurotoxic activity of the tetrahalogenated pyrethroids, tralomethrin and tralocythrin, which are dibromo adducts of deltamethrin and RU 24501, respectively, and RU 27218, which is a dichloro adduct of RU 24501, have been studied on two different excitable membranes using in vitro methods: insect axonal membranes and mammalian neuroblastoma cells in culture. The results show that molecules whose chrysanthemic acid chain at C 3 is saturated by halogen addition have intrinsic toxicity on the sodium channels of nerve membranes. They increase the amplitude of negative after-potential, depolarize the cockroach axonal membrane, and stabilize an open conformation of voltage-dependent Na + channels in mouse neuroblastoma cells, thereby producing a massive uptakeof Na + by the cells. All effects were observed in the absence of metabolic transformation of the compounds tested. In light of these experiments, it is concluded that tralomethrin and tralocythrin cannot be considered as propyrethroids.