FutureTox III: Bridges for Translation

Future Tox III, a Society of Toxicology Contemporary Concepts in Toxicology workshop, was held in November 2015. Building upon Future Tox I and II, Future Tox III was focused on developing the high throughput risk assessment paradigm and taking the science of in vitro data and in silico models forwa...

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Published inToxicological Sciences Vol. 155; no. 1; pp. 22 - 31
Main Authors Juberg, Daland R, Knudsen, Thomas B, Sander, Miriam, Beck, Nancy B, Faustman, Elaine M, Mendrick, Donna L, Fowle, 3rd, John R, Hartung, Thomas, Tice, Raymond R, Lemazurier, Emmanuel, Becker, Richard A, Fitzpatrick, Suzanne Compton, Daston, George P, Harrill, Alison, Hines, Ronald N, Keller, Douglas A, Lipscomb, John C, Watson, David, Bahadori, Tina, Crofton, Kevin M
Format Journal Article
LanguageEnglish
Published United States Oxford University Press (OUP) 01.01.2017
Oxford University Press
Subjects
Animals
Environmental Sciences
Forum: Future Tox III
Humans
In Vitro Techniques
Toxicity Tests
Toxicology
risk assessment
testing alternatives
in vitro and alternatives
regulatory/policy
predictive toxicology
PREDICTIVE TOXICOLOGY
TESTING ALTERNATIVES
RISK ASSESSMENT
IN VITRO AND ALTERNATIVES
REGULATORY/POLICY
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Summary:Future Tox III, a Society of Toxicology Contemporary Concepts in Toxicology workshop, was held in November 2015. Building upon Future Tox I and II, Future Tox III was focused on developing the high throughput risk assessment paradigm and taking the science of in vitro data and in silico models forward to explore the question-what progress is being made to address challenges in implementing the emerging big-data toolbox for risk assessment and regulatory decision-making. This article reports on the outcome of the workshop including 2 examples of where advancements in predictive toxicology approaches are being applied within Federal agencies, where opportunities remain within the exposome and AOP domains, and how collectively the toxicology community across multiple sectors can continue to bridge the translation from historical approaches to Tox21 implementation relative to risk assessment and regulatory decision-making.
Bibliography:PMCID: PMC6080854
Disclaimer: The views expressed in this article are those of the authors and do not necessarily reflect the views or policies of the U.S. Environmental Protection Agency, the National Institute of Environmental Health Sciences, the National Institutes of Health, the U.S. Food and Drug Administration, or any other U.S. federal institute or agency. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.
ISSN:1096-6080
1096-0929
1096-6099
DOI:10.1093/toxsci/kfw194