Glucose intolerance during decreased physical activity in man

Impaired glucose tolerance is a well documented consequence of absolute bedrest in man. Previous studies have shown a decrease in forearm glucose uptake during intravenous glucose infusion after fourteen days of bedrest. Bedrest is associated not only with physical inactivity but with a change in gr...

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Published inDiabetes (New York, N.Y.) Vol. 21; no. 2; pp. 101 - 107
Main Authors Lipman, R L, Raskin, P, Love, T, Triebwasser, J, Lecocq, F R, Schnure, J J
Format Journal Article
LanguageEnglish
Published United States 01.02.1972
Subjects
Adolescent
Adult
Animals
Blood Glucose - analysis
Fasting
Glucose - administration & dosage
Glucose Tolerance Test
Haplorhini
Humans
Injections, Intravenous
Insulin - blood
Male
Physical Exertion
Regional Blood Flow
Rest
Time Factors
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Summary:Impaired glucose tolerance is a well documented consequence of absolute bedrest in man. Previous studies have shown a decrease in forearm glucose uptake during intravenous glucose infusion after fourteen days of bedrest. Bedrest is associated not only with physical inactivity but with a change in gravitational vector. This study was designed to examine the individual contributions of these factors to the glucose intolerance of bedrest. Thus, glucose tolerance tests were carried out in exercising subjects at bedrest and in rhesus monkeys immobilized in the vertical plane. Exercise in man improved glucose tolerance during bedrest, and vertically immobilized monkeys demonstrated significant glucose intolerance. It is concluded that the glucose intolerance of bedrest is a function of the decrease in physical activity.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0012-1797
1939-327X
DOI:10.2337/diab.21.2.101