Association of symptoms of psychiatric disease and electroencephalographic patterns in idiopathic generalized epilepsy

• Published in: Epilepsy & behavior Vol. 145; p. 109293
• Main Authors: Mangaard, Sofie, Gesche, Joanna, Krøigård, Thomas, Beier, Christoph P.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2023
• Subjects: Drug resistance; Electroencephalography; Electroencephalography - methods; Epilepsy; Epilepsy, Generalized - complications; Epilepsy, Generalized - diagnosis; Epilepsy, Generalized - genetics; Humans; Idiopathic Generalized Epilepsy; Immunoglobulin E; Impulsivity; JME; Mental Disorders; Psychiatric comorbidity; Seizures - diagnosis; Impulsivity; Idiopathic Generalized Epilepsy; Electroencephalography; JME; Psychiatric comorbidity; Drug resistance
• ISSN: 1525-5050; 1525-5069
• DOI: 10.1016/j.yebeh.2023.109293

•Self-reported symptoms of anxiety were associated with epileptic discharges on EEG and recent seizures.•Symptoms of depression, personality disorder, anxiety, and impulsivity were not independently associated with the frequency of epileptic discharges.•Our data are not compatible with a strong link between the extent of EEG changes and self-reported psychiatric symptoms. Idiopathic generalized epilepsies (IGE) are genetic epilepsies with alterations of thalamo-frontocortical circuits that play a major role in seizure generation and propagation. Psychiatric diseases and drug resistance are strongly associated, but it remains unknown if they are symptoms of the same pathophysiological process. Hypothesizing that the same network alterations are associated with the frequency of epileptic discharges (ED) and psychiatric symptoms, we here tested the association of self-reported psychiatric symptoms and IGE severity estimated by electroencephalographic (EEG) biomarkers. Idiopathic generalized epilepsies patients were asked to fill out four validated psychiatric screening tools assessing symptoms of personality disorders (Standard Assessment of Personality- Abbreviated Scale), depression (Major Depression Inventory), impulsiveness (Barratt Impulsiveness Scale), and anxiety (brief Epilepsy Anxiety Survey Instrument). Blinded to results and clinical data on the patients, we analyzed the patients’ EEGs, assessed, and quantified ED. The number and duration of ED divided by the duration of the EEG served as a proxy for the severity of IGE that was correlated with the results of the psychiatric screening. Paired data from 64 patients were available for analysis. The duration of EDs per minute EEG was inversely associated with the time since the last seizure. The number of patients with generalized polyspike trains (n = 2), generalized paroxysmal fast activity (n = 3), and prolonged epileptiform discharges (n = 10) were too low for statistically meaningful analyses. Self-reported symptoms of depression, personality disorder, and impulsivity were not associated with EDs. In contrast, the duration of EDs per minute EEG was associated with self-reported symptoms of anxiety in univariate analyses, not significant, however, following adjustment for time since the last seizure in regression models. Self-reported symptoms of psychiatric diseases were not strongly associated with EDs as the best available quantifiable biomarker of IGE severity. As expected, the duration of EDs per minute and anxiety was inversely associated with time since the last seizure. Our data argue against a direct link between the frequency of EDs – as an objective proxy of IGE severity – and psychiatric symptoms.