Early HIV-specific cytotoxic T lymphocytes and disease progression in children born to HIV-infected mothers

The activities of HIV-specific cytotoxic T lymphocytes (CTLs) were evaluated in 10 HIV-infected children, born to infected mothers who did not receive AZT during pregnancy. CTL activities were present as early as 4 months of age. The five children that progressed to AIDS before 1 year of age had red...

Full description

Saved in:
Bibliographic Details
Published inAIDS research and human retroviruses Vol. 14; no. 16; p. 1435
Main Authors Buseyne, F, Burgard, M, Teglas, J P, Bui, E, Rouzioux, C, Mayaux, M J, Blanche, S, Rivière, Y
Format Journal Article
LanguageEnglish
Published United States 01.11.1998
Subjects
Child
Child, Preschool
Disease Progression
Female
Follow-Up Studies
HIV Infections - immunology
HIV Infections - physiopathology
HIV Infections - virology
Humans
Infant
Infant, Newborn
Pregnancy
Pregnancy Complications, Infectious - virology
T-Lymphocytes, Cytotoxic - immunology
Online AccessGet more information

Cover

More Information
Summary:The activities of HIV-specific cytotoxic T lymphocytes (CTLs) were evaluated in 10 HIV-infected children, born to infected mothers who did not receive AZT during pregnancy. CTL activities were present as early as 4 months of age. The five children that progressed to AIDS before 1 year of age had reduced in vivo and in vitro CTL activities, when compared with children who remained AIDS free after 1 year of age. The latter children had weak in vivo activated CTL responses but strong memory CTLs. No relation was found between viral load, lymphocyte populations, and CTL responses between birth and 6 months of age. Between 7 and 12 months old, children with broader in vitro activated CTLs had higher absolute numbers of CD4+ and CD8+ T lymphocytes and lower plasma viral load. These data support a beneficial role of CTLs in pediatric HIV infection.
ISSN:0889-2229
DOI:10.1089/aid.1998.14.1435