Cytotoxic pyranonaphthoquinones from Melloa quadrivalvis (bignoniaceae)

Three new pyranonaphthoquinones: 5-hydroxy-6-methoxy-α-lapachone, 5,6-dihydroxy-α-lapachone and 4′,5-dihydroxy-6-methoxy-α-lapachone, and two known compounds: lapachol and 5,5′-dihydroxy-3′,4′,7-trimethoxyflavanone, were isolated from the stem bark of Melloa quadrivalvis. Their structures were estab...

Full description

Saved in:
Bibliographic Details
Published inNatural product research Vol. 19; no. 3; pp. 217 - 222
Main Authors De Andrade Lima, Cláudia S., De Amorim, Elba L.C., Nascimento, Silene C., De Araújo, Christiane F., Agra, Maria F., Barbosa-Filho, José M., Silva, Marcelo S., Da-Cunha, Emídio V.L., Curcino Vieira, Ivo J., Braz-Filho, Raimundo
Format Journal Article
LanguageEnglish
Published Taylor & Francis Group 01.04.2005
Subjects
Bignoniaceae
Cytotoxicity
Melloa quadrivalvis
Pyranonaphthoquinone
Online AccessGet full text

Cover

More Information
Summary:Three new pyranonaphthoquinones: 5-hydroxy-6-methoxy-α-lapachone, 5,6-dihydroxy-α-lapachone and 4′,5-dihydroxy-6-methoxy-α-lapachone, and two known compounds: lapachol and 5,5′-dihydroxy-3′,4′,7-trimethoxyflavanone, were isolated from the stem bark of Melloa quadrivalvis. Their structures were established by spectrometric data, mainly 1D- and 2D-NMR and mass spectra. The methylazoetetrazolium (MTT) method using viable cells of the strain Hep2 and the strain NCIH-292 demonstrated cytotoxic activity. The CI 50 was also calculated. The chloroform extract and 5-hydroxy-6-methoxy-α-lapachone inhibited cell growth.
ISSN:1478-6419
1478-6427
DOI:10.1080/1478641042000223808