[F-18]-Fluoride capture and release: azeotropic drying free nucleophilic aromatic radiofluorination assisted by a phosphonium borane

[F-18]-Fluoride ready for aromatic nucleophilic substitution was prepared according to a simple process including trapping of aqueous [F-18]-fluoride on a cartridge pre-loaded with the phosphonium borane [(Ph2MeP)C6H4(BMes(2))](+), then releasing by elution of TBACN in dry acetonitrile. Subsequent r...

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Published inChemical communications (Cambridge, England) Vol. 53; no. 2; pp. 340 - 343
Main Authors Perrio, Cecile, Schmitt, Sebastien, Pla, Daniel, Gabbai, Francois P., Chansaenpak, Kantapat, Mestre-Voegtle, Beatrice, Gras, Emmanuel
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 2017
Royal Society of Chemistry
Subjects
Acetonitrile
Acetonitriles - chemistry
Boranes
Boranes - chemistry
Cartridges
Chemical Sciences
Chemistry
Chemistry, Multidisciplinary
Drying
Elution
Fluorides - chemistry
Fluorine Radioisotopes - chemistry
Halogenation
Physical Sciences
Radiochemistry - methods
Releasing
Science & Technology
Trapping
F-18 SETOPERONE
RESIN
POSITRON-EMISSION-TOMOGRAPHY
RADIOPHARMACEUTICALS
FLUORIDE-ION
EXCHANGE
COMPLEXATION
PET
CYANIDE
WATER
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Summary:[F-18]-Fluoride ready for aromatic nucleophilic substitution was prepared according to a simple process including trapping of aqueous [F-18]-fluoride on a cartridge pre-loaded with the phosphonium borane [(Ph2MeP)C6H4(BMes(2))](+), then releasing by elution of TBACN in dry acetonitrile. Subsequent radiofluorination was successfully applied to a model reaction and to the radiosynthesis of [F-18]-setoperone.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc05168e