Cholesterol absorption and excretion in ileostomy subjects on high- and low-dietary-cholesterol intakes

• Published in: The American journal of clinical nutrition Vol. 59; no. 1; pp. 48 - 52
• Main Authors: Ellegård, L, Bosaeus, I
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.01.1994; American Society for Clinical Nutrition; American Society for Clinical Nutrition, Inc
• Subjects: ABSORCION DIGESTIVA; ABSORPTION DIGESTIVE; administration & dosage; Adult; Aged; bile acids excretion; Biological and medical sciences; CHOLESTEROL; Cholesterol absorption; Cholesterol, Dietary; Cholesterol, Dietary - administration & dosage; Cholesterol, Dietary - pharmacokinetics; COLESTEROL; DIETA; EXCRECION; EXCRETION; EXPERIMENTACION; experimental diets; EXPERIMENTATION; Female; FEMME; HOMBRES; HOMME; Humans; iheostomy subjects; Ileostomy; INGESTION DE NUTRIENTES; INGESTION DE SUBSTANCES NUTRITIVES; INTESTIN; Intestinal Absorption; INTESTINOS; Male; Medical sciences; men; Middle Aged; MUJERES; nutrient intake; OPERACIONES QUIRURGICAS; OPERATION CHIRURGICALE; pharmacokinetics; REGIME ALIMENTAIRE; Stomach, duodenum, intestine, rectum, anus; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the digestive system; Time Factors; women; β-sitosterol; β-sitosterol; Cholesterol absorption; iheostomy subjects; bile acids excretion; Human; Sitosterol; Ileostomy; Excretion; Absorption; Bile acid; Lipids; Cholesterol
• ISSN: 0002-9165; 1938-3207
• DOI: 10.1093/ajcn/59.1.48

Six healthy ileostomy subjects were given [3H]cholesterol and [14C]β-sitosterol in a single meal together with two controlled diets containing 150 or 450 mg cholesterol/ d. Each diet was eaten for 3 d. Cholesterol absorption and excretion of cholesterol, bile acids, fat, energy, and nitrogen were analyzed. Fractional cholesterol absorption increased from 44 ± 2.6% (x̄ ± SE) to 61 ± 3.4% (P < 0.05), but absolute cholesterol absorption decreased from 191 ±11 to 94 ±9 mg/d (P < 0.05) on low cholesterol intake compared with high cholesterol intake. Weight of ileostomy effluent, or excretion of energy, nitrogen, fat, and bile acids did not differ between periods. Endogenous cholesterol excretion remained unchanged whereas net cholesterol excretion (output minus intake) was 37% higher (P < 0.05) on low compared with high cholesterol intake.