Photoacoustic/ultrasound dual-modality imaging for marker clip localization in neoadjuvant chemotherapy of breast cancer

• Published in: Journal of biomedical optics Vol. 29; no. Suppl 1; p. S11525
• Main Authors: Deng, Handi, Bai, Yizhou, Xiang, Jiaxuan, Li, Zhaoyue, Zhao, Peiliang, Shi, Yawen, Fu, Wubing, Chen, Yuwen, Fu, Minggang, Ma, Cheng, Luo, Bin
• Format: Journal Article
• Language: English
• Published: United States Society of Photo-Optical Instrumentation Engineers 01.01.2024
• Subjects: Special Issue Honoring Lihong V. Wang, Pioneer in Biomedical Optics; neoadjuvant chemotherapy; tumor localization; marker clip; PA/US dual-modality imaging
• ISSN: 1083-3668; 1560-2281
• DOI: 10.1117/1.JBO.29.S1.S11525

To ensure precise tumor localization and subsequent pathological examination, a metal marker clip (MC) is placed within the tumor or lymph node prior to neoadjuvant chemotherapy for breast cancer. However, as tumors decrease in size following treatment, detecting the MC using ultrasound imaging becomes challenging in some patients. Consequently, a mammogram is often required to pinpoint the MC, resulting in additional radiation exposure, time expenditure, and increased costs. Dual-modality imaging, combining photoacoustic (PA) and ultrasound (US), offers a promising solution to this issue. Our objective is to localize the MC without radiation exposure using PA/US dual-modality imaging. A PA/US dual-modality imaging system was developed. Utilizing this system, both phantom and clinical experiments were conducted to demonstrate that PA/US dual-modality imaging can effectively localize the MC. The PA/US dual-modality imaging can identify and localize the MC. In clinical trials encompassing four patients and five MCs, the recognition rate was . Three experiments to verify the accuracy of marker position recognition were successful. We effectively localized the MC in real time using PA/US dual-modality imaging. Unlike other techniques, the new method enables surgeons to pinpoint nodules both preoperatively and intraoperatively. In addition, it boasts non-radioactivity and is comparatively cost-effective.