Array synthesis of novel lipodepsipeptide

• Published in: Bioorganic & medicinal chemistry letters Vol. 13; no. 23; pp. 4245 - 4249
• Main Authors: Siedlecki, James, Hill, Jason, Parr, Ian, Yu, Xiang, Morytko, Michael, Zhang, Yanzhi, Silverman, Jared, Controneo, Nicole, Laganas, Valerie, Li, Tongchuan, Li, Jianshi, Keith, Dennis, Shimer, George, Finn, John
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2003
• Subjects: Alkylation; Amides - chemistry; Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - pharmacology; Combinatorial Chemistry Techniques; Daptomycin - analogs & derivatives; Daptomycin - chemical synthesis; Daptomycin - pharmacology; Drug Design; Enterococcus faecalis - drug effects; Enterococcus faecium - drug effects; Lipids - chemistry; Microbial Sensitivity Tests; Molecular Structure; Oxidation-Reduction; Peptides, Cyclic - chemical synthesis; Peptides, Cyclic - pharmacology; Piperazine; Piperazines - chemistry; Staphylococcus aureus - drug effects; Structure-Activity Relationship; Sulfonamides - chemistry
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/j.bmcl.2003.07.025

Synthetic array technology was utilized to rapidly synthesize and analyze a diverse set of reductive alkylation analogues of daptomycin. Analysis of the array suggested the use of polar functionality such as sulfonamides or amide or polar spaces such as piperazine would beneficially affect activity. Synthetic array technology was utilized to rapidly synthesize and analyze a diverse set of reductive alkylation analogues of daptomycin. Analysis of the array suggested the use of polar functionality such as sulfonamides or amide or polar spaces such as piperazine would beneficially affect activity.