Tongue-coating microbiome as a cancer predictor: A scoping review

• Published in: Archives of oral biology Vol. 132; p. 105271
• Main Authors: Ali Mohammed, Marwan Mansoor, Al Kawas, Sausan, Al-Qadhi, Gamilah
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.12.2021
• Subjects: Bacterial abundance; Cancer; Dentistry; Microbial diversity; Precancerous; Tongue coating; Tongue microbiome; Tongue coating; cAMP CREB-1; MAMPs; NF-kB; Microbial diversity; IL-1β; IL-8; STAT; IFI16; HIV; TNF-α; Precancerous; RNS; ROS; Bacterial abundance; Tongue microbiome; NGS; NLRs; TLRs; Cancer
• ISSN: 0003-9969; 1879-1506
• DOI: 10.1016/j.archoralbio.2021.105271

The tongue microbiome has emerged as a non-invasive diagnostic and tracking prognostic tool in the detection of diseases mainly cancer. This scoping review aimed to identify the association between tongue microbiome and pre-cancer or cancer lesions. A comprehensive electronic database search including PubMed, Web of Science, and Scopus was undertaken up to March 2021, without language or date restrictions. This review was conducted following the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guideline. All observational studies that compared microbial community on the dorsal surface of the tongue between cancer or precancerous cases and healthy controls using NGS techniques were included. Of 274 records identified, nine studies were eligible to be included. Despite the inconsistent observations in terms of diversity and richness, most studies reported alteration in bacterial communities between pre-cancer or cancer cases and control groups. The bacterial profile among cases was so far correlated at the phylum level with a noticeable diverse degree at the genus level. The majority of included studies reported a higher abundance of certain kinds of microorganisms as compared to healthy participants including Firmicutes, Fusobacteria and Actinobacteria at phyla level as well as Streptococcus, Actinomyces, Leptotrichia, Campylobacter, and Fusobacterium at the genus level. The alteration of the tongue microbial community has been associated with several diseases mainly cancer. So, the tongue microbiome may serve as a promising diagnostic tool or as a long-term monitor in precancerous or cancer cases. •Tongue dorsum is one of the most important microbial niches in the human body.•Alteration of the tongue microbial community has been associated with many diseases.•Tongue microbiome could be an effective predictive tool for cancerous lesions.•Cases showed a higher abundance of certain kinds of bacteria compared to non-cases.