[1-(11)C]acetate uptake is not increased in renal cell carcinoma

• Published in: European journal of nuclear medicine and molecular imaging Vol. 34; no. 6; pp. 884 - 888
• Main Authors: Kotzerke, J, Linné, C, Meinhardt, M, Steinbach, J, Wirth, M, Baretton, G, Abolmaali, N, Beuthien-Baumann, B
• Format: Journal Article
• Language: English
• Published: Germany Springer Nature B.V 01.06.2007
• Subjects: Acetates - chemistry; Acetates - pharmacokinetics; Acetic acid; Adult; Aged; Aged, 80 and over; Cancer; Carbon Radioisotopes - pharmacokinetics; Carcinoma, Renal Cell - diagnostic imaging; Female; Histology; Humans; Kidney - diagnostic imaging; Kidney - metabolism; Kidney cancer; Kidney Neoplasms - diagnostic imaging; Kidneys; Magnetic resonance imaging; Male; Metabolism; Middle Aged; Nuclear medicine; Parenchyma; Positron-Emission Tomography - methods; Renal cell carcinoma; Time Factors; Tumors
• ISSN: 1619-7070; 1619-7089
• DOI: 10.1007/s00259-006-0362-5

The purpose of this study was to investigate the potential of [1-(11)C]acetate (AC) as a metabolic tracer for renal cell cancer in human subjects. Twenty-one patients with suspected kidney tumours were investigated with AC and dynamic PET. AC uptake was scored on a five-step scale. Tumour localisation was known from CT/MRI. Histology was available in 18/21 patients. The results in these 18 patients are reported. AC uptake by the tumour was less than (n=11), equal to (n=5) or higher than (n=2) uptake in the surrounding renal parenchyma. Histological tumour types showed a typical distribution, with a predominance of clear cell carcinomas (n=14) and only a small number of papillary cell carcinomas (n=2) and oncocytomas (n=2). Only the benign oncocytomas were highly positive with AC. In most kidney tumours the AC accumulation was not higher than in normal kidney parenchyma. Therefore, AC PET cannot be recommend for the characterisation of a renal mass.