Protective effect of phenolic extract of Cyperus rotundus rhizomes on myocardial infarction induced by isoproterenol in female rats

• Published in: IOP conference series. Materials Science and Engineering Vol. 454; no. 1; pp. 12005 - 12009
• Main Authors: Majid, Alyaa, Sayer, S A
• Format: Journal Article
• Language: English
• Published: Bristol IOP Publishing 01.12.2018
• Subjects: Biochemistry; Dimers; Electrolytes; Heart attacks; Isopreterenol; Isoproterenol; Myocardial infarction; Myocardial infraction
• ISSN: 1757-8981; 1757-899X; 1757-899X
• DOI: 10.1088/1757-899X/454/1/012005

Objective: To asses the protective effect of phenolic extract of cyperus rotundus rhizomes on biochemical in isoproterenol induced myocardial infraction. Methods: Myocardial infarction was induced in rats by intraperitoneally injection of isoproterenol (85mg/kg) for two consecutive days at an interval of 24 h. Rats were treated with phenolic extract of cyperus rotundus rhizomes at two doses (15mg/kg, 30 mg/kg) for period 21 days and isoproterenol was injected on the 21th and 22th day. At the end of experiment i.e. on the 23th day biochemical changes were monitored from control and experimental groups. Results: ISO injected rats showed a significant increase in d-dimer levels. In addition, it also exhibited alteration in the levels of electrolytes (Na+ and Cl−). It also showed significant decrease in level of K+. Pretreatment with phenolic extract of cyperus rotundus rhizomes significantly prevented the ISO induced alteration in biochemical changes. Conclusions: The present result shows that treatment with phenolic extract of cyperus rotundus rhizomes in ISO injected rats significantly attenuates induced myocardial infarction.