Distressed personality is associated with late adverse effects in long-term survivors of Hodgkin lymphoma

• Published in: Acta oncologica Vol. 63; no. 1; pp. 600 - 606
• Main Authors: Dahl, Alv A, Smeland, Knut B, Eikeland, Siri, Fagerli, Unn-Merete, Bersvendsen, Hanne S, Fosså, Alexander, Kiserud, Cecilie E
• Format: Journal Article
• Language: English
• Published: Sweden MJS Publishing on behalf of Acta Oncologica 04.08.2024; Medical Journals Sweden
• Subjects: Adolescent; Adult; Cancer survivors; Cancer Survivors - psychology; Cancer Survivors - statistics & numerical data; Child; Cross-Sectional Studies; Fatigue - epidemiology; Fatigue - etiology; Fatigue - psychology; Female; Hodgkin Disease - psychology; Hodgkin lymphoma; Humans; Late adverse effects; Long Term Adverse Effects - epidemiology; Long Term Adverse Effects - etiology; Long Term Adverse Effects - psychology; Male; Middle Aged; Original; Personality; Sleep Wake Disorders - epidemiology; Sleep Wake Disorders - etiology; Sleep Wake Disorders - psychology; Stress Disorders, Post-Traumatic - epidemiology; Stress Disorders, Post-Traumatic - etiology; Stress Disorders, Post-Traumatic - psychology; Surveys and Questionnaires; type D personality; Young Adult
• ISSN: 0284-186X; 1651-226X; 1651-226X
• DOI: 10.2340/1651-226X.2024.40312

There are few studies of personality traits in long-term Hodgkin lymphoma survivors (HLSs) treated according to contemporary stage-and risk-adapted approaches. The Distressed Personality (DP) Scale covers negative affectivity and social inhibition. We examined differences in self-reported late adverse effects (LAEs) between HLSs with and without DP and other explanatory variables. This cross-sectional questionnaire-based study included a population-based cohort of HLSs treated from 1997 to 2006, aged 8-49 years at diagnosis, and alive in 2016. Among 518 eligible HLSs, 303 responded (58%), and 294 completed the DP scale. DP was defined by scores above cut-off on both the negative affectivity and social inhibition subscales. LAEs studied were major depression, posttraumatic stress disorder, sleep problems, obesity, neuropathy, fatigue, memory problems, and general health. DP and 10 other explanatory variables were tested against LAEs as dependent variables in multivariable regression analyses. The mean age at survey was 45.9 years (standard deviation [SD] 4.6), mean follow-up time 16.7 years (SD 3.0), and 48% were females. Eighty-two HLSs had DP (28%, 95% confidence interval 23% - 33%). All LAEs except obesity were significantly more common/had higher mean score in HLSs with DP. In multivariable analyses, presence of DP was significantly associated with all LAEs except obesity. The presence of DP is common among HLSs. The presence of DP was associated with most self-report LAEs examined. Including assessment of personality traits in the survivorship care plans of HLSs should be considered. Prospective studies assessing the influence of pretreatment DP on LAEs are warranted.