Hyperforin: To Be or Not to Be an Activator of TRPC(6)

• Published in: Reviews of physiology, biochemistry and pharmacology Vol. 169; p. 1
• Main Authors: Friedland, Kristina, Harteneck, Christian
• Format: Journal Article
• Language: English
• Published: Germany 01.01.2015
• Subjects: Animals; Cytochrome P-450 Enzyme Inducers - pharmacology; Drug Stability; Humans; Phloroglucinol - analogs & derivatives; Phloroglucinol - chemistry; Phloroglucinol - pharmacology; Terpenes - chemistry; Terpenes - pharmacology; TRPC Cation Channels - drug effects; TRPC Cation Channels - physiology; TRPC6 Cation Channel; Hyperforin; TRP channel; Depression; Protonophore; Ion channel; Calcium homeostasis; St. John's wort

Meantime, it is well accepted that hyperforin, the chemical instable phloroglucinol derivative of Hypericum perforatum, St. John's wort, is the pharmacophore of St. John's wort extracts. With the decline of this scientific discussion, another controversial aspect has been arisen, the quest...