Hyperforin: To Be or Not to Be an Activator of TRPC(6)

Meantime, it is well accepted that hyperforin, the chemical instable phloroglucinol derivative of Hypericum perforatum, St. John's wort, is the pharmacophore of St. John's wort extracts. With the decline of this scientific discussion, another controversial aspect has been arisen, the quest...

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Bibliographic Details
Published inReviews of physiology, biochemistry and pharmacology Vol. 169; p. 1
Main Authors Friedland, Kristina, Harteneck, Christian
Format Journal Article
LanguageEnglish
Published Germany 01.01.2015
Subjects
Animals
Cytochrome P-450 Enzyme Inducers - pharmacology
Drug Stability
Humans
Phloroglucinol - analogs & derivatives
Phloroglucinol - chemistry
Phloroglucinol - pharmacology
Terpenes - chemistry
Terpenes - pharmacology
TRPC Cation Channels - drug effects
TRPC Cation Channels - physiology
TRPC6 Cation Channel
Hyperforin
TRP channel
Depression
Protonophore
Ion channel
Calcium homeostasis
St. John's wort
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Summary:Meantime, it is well accepted that hyperforin, the chemical instable phloroglucinol derivative of Hypericum perforatum, St. John's wort, is the pharmacophore of St. John's wort extracts. With the decline of this scientific discussion, another controversial aspect has been arisen, the question regarding the underlying mechanism leading to the pharmacological profile of the plant extract used in therapy of depression. We will summarize the different concepts described for hyperforin's antidepressive activity. Starting with unspecific protein-independent mechanisms due to changes in pH, we will summarize data of protein-based concepts beginning with concepts based on involvement of a variety of proteins and will finally present concepts based on the modulation of a single protein.
ISSN:0303-4240
DOI:10.1007/112_2015_25