Usefulness of Atopy Patch Test on a Child with Milk Protein-Induced Enterocolitis Syndrome: A Case Report

We describe the case of a child affected by milk-protein induced enterocolitis, in which oral challenge with corn was performed without symptoms after a negative specific Atopy Patch Test. Food protein-induced enterocolitis syndrome (FPIES) is an uncommon non-IgE-mediated gastrointestinal food hyper...

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Bibliographic Details
Published inInternational journal of immunopathology and pharmacology Vol. 26; no. 3; pp. 795 - 800
Main Authors Scaparrotta, A., Di Pillo, S., Consilvio, N.P., Attanasi, M., Cingolani, A., Rapino, D., Cerasa, M., Pucci, N., Di Gioacchino, M., Chiarelli, F.
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.07.2013
Subjects
Breast Feeding
Enterocolitis - diagnosis
Enterocolitis - immunology
Humans
Infant
Infant Formula
Male
Milk Hypersensitivity - diagnosis
Milk Hypersensitivity - immunology
Milk Proteins - adverse effects
Patch Tests
Predictive Value of Tests
Syndrome
atopy patch test
immunologic alterations
pathogenetic mechanism
food protein-induced enterocolitis syndrome
oral challenge
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Summary:We describe the case of a child affected by milk-protein induced enterocolitis, in which oral challenge with corn was performed without symptoms after a negative specific Atopy Patch Test. Food protein-induced enterocolitis syndrome (FPIES) is an uncommon non-IgE-mediated gastrointestinal food hypersensitivity of infancy, characterized by severe vomiting and diarrhea arising within 1 to 3 hours after ingestion of the causative food. Little is known about the pathophysiology of FPIES. The absence of food-specific IgE as demonstrated by negative skin prick tests suggests that the disease is not caused by an early onset IgE-mediated reaction. Atopy Patch Test has been described as sensitive and predictive in this syndrome. The hypothesis on the immunological pathogenesis has been discussed on the basis of literature data.
ISSN:0394-6320
2058-7384
DOI:10.1177/039463201302600327