Thymus: Role in Resistance to Polyoma Virus Oncogenesis

• Published in: Science (American Association for the Advancement of Science) Vol. 147; no. 3654; pp. 164 - 165
• Main Author: Law, Lloyd W.
• Format: Journal Article
• Language: English
• Published: United States American Association for the Advancement of Science 08.01.1965
• Subjects: Animals; Animals, Newborn; Antigens; Cell Transformation, Neoplastic; Lymphocytes; Mice; Mice, Inbred C57BL; Neoplasia; Neoplasms - etiology; Neoplasms - immunology; Neoplasms, Experimental; Old Medline; Polyomavirus; Spleen; Spleen cells; Spore discharge; Thymectomy; Thymus Gland; Transplantation immunology; Tumors; Viruses; NEOPLASM IMMUNOLOGY; THYMUS GLAND; EXPERIMENTAL LAB STUDY; MICE; THYMECTOMY; POLYOMA VIRUS; NEOPLASM ETIOLOGY; NEOPLASMS, EXPERIMENTAL; ANIMALS, NEWBORN

Mice of the C57BL strain are highly resistant to the oncogenic property of LID-1 polyoma virus, but complete thymectomy within 24 hours of birth rendered these mice susceptible. In thymectomized mice inoculated with adult syngeneic spleen cells, the capacity to resist oncogenesis was restored. The r...