Thymus: Role in Resistance to Polyoma Virus Oncogenesis

Mice of the C57BL strain are highly resistant to the oncogenic property of LID-1 polyoma virus, but complete thymectomy within 24 hours of birth rendered these mice susceptible. In thymectomized mice inoculated with adult syngeneic spleen cells, the capacity to resist oncogenesis was restored. The r...

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Bibliographic Details
Published inScience (American Association for the Advancement of Science) Vol. 147; no. 3654; pp. 164 - 165
Main Author Law, Lloyd W.
Format Journal Article
LanguageEnglish
Published United States American Association for the Advancement of Science 08.01.1965
Subjects
Animals
Animals, Newborn
Antigens
Cell Transformation, Neoplastic
Lymphocytes
Mice
Mice, Inbred C57BL
Neoplasia
Neoplasms - etiology
Neoplasms - immunology
Neoplasms, Experimental
Old Medline
Polyomavirus
Spleen
Spleen cells
Spore discharge
Thymectomy
Thymus Gland
Transplantation immunology
Tumors
Viruses
NEOPLASM IMMUNOLOGY
THYMUS GLAND
EXPERIMENTAL LAB STUDY
MICE
THYMECTOMY
POLYOMA VIRUS
NEOPLASM ETIOLOGY
NEOPLASMS, EXPERIMENTAL
ANIMALS, NEWBORN
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Summary:Mice of the C57BL strain are highly resistant to the oncogenic property of LID-1 polyoma virus, but complete thymectomy within 24 hours of birth rendered these mice susceptible. In thymectomized mice inoculated with adult syngeneic spleen cells, the capacity to resist oncogenesis was restored. The results add further weight to the concept that induction and progression of tumors by polyoma virus has an immunologic basis.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0036-8075
1095-9203
DOI:10.1126/science.147.3654.164