A Prospective, Multicentre Case-Control Trial Examining Factors That Explain Variable Clinical Performance in Post Lingual Adult CI Recipients

• Published in: Trends in hearing Vol. 29; p. 23312165251347138
• Main Authors: Dawson, Pam, Fullerton, Amanda, Krishnamoorthi, Harish, Plant, Kerrie, Cowan, Robert, Buczak, Nadine, Long, Christopher, James, Chris J., Sismono, Fergio, Büchner, Andreas
• Format: Journal Article
• Language: English
• Published: United States SAGE Publications 01.01.2025
• Subjects: Adult; Aged; Auditory Threshold; Case-Control Studies; Cochlear Implantation - adverse effects; Cochlear Implantation - instrumentation; Cochlear Implants; Cognition; Female; Humans; Male; Middle Aged; Persons with Hearing Disabilities - psychology; Persons with Hearing Disabilities - rehabilitation; Prospective Studies; Speech Perception; Tongue; Treatment Outcome; sound processor mapping; cochlear implant; cognition; predictive factors; neural health; speech perception; electrode placement
• ISSN: 2331-2165; 2331-2165
• DOI: 10.1177/23312165251347138

This study investigated which of a range of factors could explain performance in two distinct groups of experienced, adult cochlear implant recipients differentiated by performance on words in quiet: 72 with poorer word scores versus 77 with better word scores. Tests measured the potential contribution of sound processor mapping, electrode placement, neural health, impedance, cognitive, and patient-related factors in predicting performance. A systematically measured sound processor MAP was compared to the subject's walk-in MAP. Electrode placement included modiolar distance, basal and apical insertion angle, and presence of scalar translocation. Neural health measurements included bipolar thresholds, polarity effect using asymmetrical pulses, and evoked compound action potential (ECAP) measures such as the interphase gap (IPG) effect, total refractory time, and panoramic ECAP. Impedance measurements included trans impedance matrix and four-point impedance. Cognitive tests comprised vocabulary ability, the Stroop test, and the Symbol Digits Modality Test. Performance was measured with words in quiet and sentence in noise tests and basic auditory sensitivity measures including phoneme discrimination in noise and quiet, amplitude modulation detection thresholds and quick spectral modulation detection. A range of predictor variables accounted for between 33% and 60% of the variability in performance outcomes. Multivariable regression analyses showed four key factors that were consistently predictive of poorer performance across several outcomes: substantially underfitted sound processor MAP thresholds, higher average bipolar thresholds, greater total refractory time, and greater IPG offset. Scalar translocation, cognitive variables, and other patient related factors were also significant predictors across more than one performance outcome.