The connection between rs6265 polymorphism in the BDNF gene and successful mastering of the video-oculographic interface

• Published in: Journal of integrative neuroscience Vol. 20; no. 2; pp. 287 - 296
• Main Authors: Turovsky, Yaroslav A, Gureev, Artem P, Vitkalova, Inna Yu, Popov, Vasily N, Vakhtin, Alexey A
• Format: Journal Article
• Language: English
• Published: Singapore IMR Press 30.06.2021
• Subjects: Adult; Brain-Computer Interfaces; brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - genetics; Brain-Derived Neurotrophic Factor - physiology; eye movement; Eye-Tracking Technology; Female; Humans; Male; Polymorphism, Single Nucleotide; Psychomotor Performance - physiology; rs6265; video-oculographic interface; working memory; Young Adult; rs6265; Brain-derived neurotrophic factor; Working memory; Eye movement; Video-oculographic interface
• ISSN: 0219-6352; 1757-448X
• DOI: 10.31083/j.jin2002028

A video-oculographic interface is a system for controlling objects using eye movements. The video-oculographic interface differs from other brain-computer interfaces regarding its improved accuracy, simplicity, and ergonomics. Despite these advantages, all users are not equally successful in mastering these various devices. It has been suggested that the genetic characteristics of the operators may determine the efficiency of video-oculographic interface mastery. We recruited healthy users with rs6313, rs2030324, rs429358, rs10119, rs457062, rs4290270, and rs6265 polymorphisms and analyzed the relationships between these polymorphisms and values of success in video-oculographic interface mastery. We found that carriers of the G/G genotype of the rs6265 polymorphism ( gene) demonstrated the best results in video-oculographic interface mastery. In contrast, carriers of the A/A genotype were characterized by large standard deviations in the average amplitude of eye movement and the range of eye movement negatively correlated with goal achievement. This can be explained through the fact that carriers of the A/A genotype demonstrate lower synaptic plasticity due to reduced expression of when compared to carriers of the G/G genotype. These results expand our understanding of the genetic predictors of successful video-oculographic interface management, which will help to optimize device management training for equipment operators and people with disabilities.