Eosinophilic Sialodochitis: A Rare Comorbidity of Severe Asthma

• Published in: Journal of investigational allergology & clinical immunology Vol. 33; no. 2; pp. 139 - 140
• Main Authors: González, O, Picado, C, Arismendi, E, Alobid, I, Ramirez, J, Valero, A, Bobolea, I
• Format: Journal Article
• Language: English
• Published: Spain Esmon Publicidad 01.01.2023
• Subjects: Allergic bronchopulmonary aspergillosis; Anti-Asthmatic Agents - therapeutic use; Anti-inflammatory agents; Aspergillosis; Asthma; Asthma - drug therapy; Asthma - epidemiology; Bronchiectasis; Charcot-Leyden crystal protein; Comorbidity; Crystals; Disease Progression; Drug tolerance; Eosinophilia; Eosinophils; Esophagitis; Humans; Immunoglobulin E; Inflammation; Leukocytes (eosinophilic); Monoclonal antibodies; Mucus; Parotid gland; Parotitis; Polyps; Rhinosinusitis; Sialodochitis; Benralizumab; Comorbidity; Asthma; Eosinophils
• ISSN: 1018-9068; 1698-0808
• DOI: 10.18176/jiaci.0817

Diseases of the parotid gland vary widely, the most frequent being obstructive sialadenitis, which can be caused by mucus plugs, salivary stones, or anatomic anomalies, although in some cases the cause remains unclear. The relationship between recurrent swelling of the parotid gland and mucus plugs containing leukocytes and Charcot-Leyden crystals was first described in 1876 by Kussmaul. Since then, similar cases, also involving eosinophilia or high serum IgE levels, have been diagnosed as "allergic parotitis" or "eosinophilic sialodochitis". We report the case of an 80-year-old woman with severe persistent eosinophilic asthma, chronic rhinosinusitis with nasal polyps with good tolerance to nonsteroidal anti-inflammatory drugs, bronchiectasis, allergic bronchopulmonary aspergillosis, and eosinophilic esophagitis. She was initially treated with omalizumab for 2 periods (2009-2013 and 2016-2021).