A circuit design of a low-cost, portable and programmable electroporation device for biomedical applications

Electroporation for transdermal drug delivery or for non-invasive monitoring of patients could allow a new generation of medical devices to be developed for low-cost healthcare. The existing electroporation systems today are bulky, expensive or not fully programmable. Therefore, a compact, low-cost...

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Published inSensors and actuators. B, Chemical Vol. 166-167; pp. 292 - 300
Main Authors Ching, Congo Tak-Shing, Sun, Tai-Ping, Huang, Wei-Ti, Huang, Su-Hua, Hsiao, Chin-Sung, Chang, Kang-Ming
Format Journal Article
LanguageEnglish
Published Elsevier B.V 20.05.2012
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Summary:Electroporation for transdermal drug delivery or for non-invasive monitoring of patients could allow a new generation of medical devices to be developed for low-cost healthcare. The existing electroporation systems today are bulky, expensive or not fully programmable. Therefore, a compact, low-cost and programmable device was developed and evaluated. A circuit is described herein which provides a variety of adjustable high-voltage (2–300V) electric waveforms (pulsed and pulsed-biphasic) for electroporation. Evaluation showed that this device provides for precise regulation of the magnitude and waveform of a high-voltage over a wide range of impedance, important for in vivo/human use. Also, the device was evaluated in vitro to be capable of enhancing transdermal extraction of metabolites, like uric acid, for non-invasive monitoring and transdermal delivery of medications, like insulin, for non-invasive drug delivery.
Bibliography:http://dx.doi.org/10.1016/j.snb.2012.02.065
ObjectType-Article-2
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ISSN:0925-4005
1873-3077
DOI:10.1016/j.snb.2012.02.065