Association between a genetic variant in scavenger receptor class B type 1 and its role on codon usage bias with increased risk of developing coronary artery disease

• Published in: Clinical biochemistry Vol. 95; pp. 60 - 65
• Main Authors: Sahebi, Reza, Ghazizadeh, Hamideh, Avan, Amir, Tayefi, Maryam, Saffar-Soflaei, Sara, Mouhebati, Mohsen, Esmaily, Habibollah, Ferns, Gordon A., Hashemzadeh-Chaleshtori, Morteza, Ghayour-Mobarhan, Majid, Farrokhi, Effat
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.09.2021
• Subjects: Coronary artery disease; Genotyping; RCSU; Risk factor; Rs5888; SCARB1; SCARB1; Genotyping; RCSU; Coronary artery disease; Rs5888; Risk factor
• ISSN: 0009-9120; 1873-2933; 1873-2933
• DOI: 10.1016/j.clinbiochem.2021.06.001

Coronary artery disease (CAD) as an important cause of morbidity and mortality globally. The scavenger receptor class B type 1 (SCARB1) plays an essential role in the reverse cholesterol transport. We have explored the association between a genetic variant, rs5888, in the SCARB1 gene with CAD and serum HDL-C levels. Patients were categorized into two groups' angiogram positive (>50% coronary stenosis) and angiogram negative (<50% coronary stenosis). Genotyping was carried out using polymerase chain reaction-amplification refractory mutation system. The association between the SNP rs5888 and serum HDL-C was analyzed using a logistic regression model. The results showed that the subjects carrying a T allele was associated with a decreased serum HDL-C levels compared to the C allele in total population (p < 0.001). The risk of angiogram positivity in subjects carrying a T allele was 3.1-fold higher than for the control group (p < 0.001). CVD patients carrying the T allele of rs5888 variant in the SCARB1 gene was associated with decreased serum level of HDL.