Antifungal principles of Baccharis pedunculata

Four compounds including a flavone, an acetylenic lactone, a prenylated coumarin, and a 3-methyl ether flavone were isolated from the dichloromethane leaf extract of Baccharis pedunculata (Mill.) Cabr. (Asteraceae). The latter three compounds were identified to be responsible for the antifungal acti...

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Bibliographic Details
Published inPlanta medica Vol. 61; no. 4; p. 360
Main Authors Rahalison, L, Benathan, M, Monod, M, Frenk, E, Gupta, M P, Solis, P N, Fuzzati, N, Hostettmann, K
Format Journal Article
LanguageEnglish
Published Germany 01.08.1995
Subjects
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
Cell Survival - drug effects
Cells, Cultured
Coumarins - isolation & purification
Coumarins - pharmacology
Flavonoids - isolation & purification
Flavonoids - pharmacology
Fungi - drug effects
Fungi - isolation & purification
Humans
Keratinocytes - cytology
Keratinocytes - drug effects
Lactones - isolation & purification
Lactones - pharmacology
Microbial Sensitivity Tests
Plant Extracts
Plant Leaves
Structure-Activity Relationship
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Summary:Four compounds including a flavone, an acetylenic lactone, a prenylated coumarin, and a 3-methyl ether flavone were isolated from the dichloromethane leaf extract of Baccharis pedunculata (Mill.) Cabr. (Asteraceae). The latter three compounds were identified to be responsible for the antifungal activity against some human pathogenic and phytopathogenic fungi. The most active compound, lachnophyllum lactone, an acetylenic lactone, showed a very high toxicity (LD50 2 micrograms/ml) against human keratinocytes.
ISSN:0032-0943
1439-0221
DOI:10.1055/s-2006-958101