PHYSICAL FRAILTY IN LIVER TRANSPLANTATION

In patients with cirrhosis, frailty represents a status of global physical dysfunction caused by undernutrition, muscle wasting and functional impairment. It is a prevalent condition in liver transplant (LT) candidates and has shown to be an independent predictor of adverse outcome. Evidence support...

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Published inRevista española de enfermedades digestivas Vol. 113; no. 7; pp. 533 - 540
Main Authors Puchades Renau, Lorena, Herreras-López, Julia, Cebrià I Iranzo, Maria Àngels, Cezón Serrano, Natalia, Berenguer Haym, Marina
Format Journal Article
LanguageEnglish
Spanish
Published Spain Sociedad Espanola de Patologia Digestivas 01.07.2021
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Summary:In patients with cirrhosis, frailty represents a status of global physical dysfunction caused by undernutrition, muscle wasting and functional impairment. It is a prevalent condition in liver transplant (LT) candidates and has shown to be an independent predictor of adverse outcome. Evidence supports its incorporation into clinical practice both as a prognostic factor guiding clinical decision-making, and as a tool to identify candidates for physical and nutritional interventions. The wide heterogeneity of instruments used for frailty measurement, the absence of a single suitable instrument for frailty assessment in all LT clinical scenarios (inpatient vs outpatient; pre-transplant vs post-transplant), and the lack of strong evidence showing a beneficial effect of frailty improvement on outcomes before and after transplantation are some of the questions that remain unanswered.
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ISSN:1130-0108
DOI:10.17235/reed.2020.7448/2020